The position of "Variation" clause in the legal order of construction contracts With emphasis on sample contracts of Iran, FIDIC and England

ABSTRACTThe variation clause is one of the common conditions in domestic and international construction contracts. Given the executive realities of construction and industrial projects, the application of this clause seems appropriate and sometimes necessary. The subject of this clause is change in the works. Changes depending on how the clause is written, including removal, increase or decrease, replacement, change of sequence and method of construction, and any changes to what the contractor has undertaken in the initial contract. Work is also a permanent and temporary work that is required to build and complete the project and is included in the contract documents such as Service description, employer requirements and technical specifications. Variation clause is the positive condition under which the contractor undertakes to execute a unilateral change order issued by the employer without the need for another agreement. It is very important to examine the variation clause in terms of limitations due to the subject and time domain as well as the legal effects of its implementation or violation. But before that, a detailed study of the legal meaning and nature of the mentioned clause and identification of its position in the legal order of constuction contract is necessary. The present article deals with the latter

The Prevalence of Musculoskeletal Disorders and its Relation with Fatigue and Occupational Burnout in the Staff of a Petrochemical Industry

Background: Occupational burnout is a sign of various fatigue states and can cause diseases like musculoskeletal disorders. The aim of this study was to determine the prevalence of musculoskeletal disorders and its relation with fatigue and occupational burnout in the staff of a petrochemical industry. Methods: The present study is a descriptive-analytical cross-sectional study conducted on 121 personnel working in a petrochemical industry in 2017. For data collection, the Multidimensional Fatigue Inventory (MFI) questionnaire, Nordic questionnaire, and Maslach Burnout questionnaire were used. Data were analyzed using SPSS 22 and the significance level was considered 0.05. Results: In general, 71.1% of the subjects suffered from at least one musculoskeletal disorder in their organs during the past year. There was no significant relation between musculoskeletal disorders and occupational burnout. Musculoskeletal disorders were significantly associated with decreased motivation (P=0.035), one of the fatigue domains. Musculoskeletal disorders were also significantly related with the type of occupation (P = 0.017). Conclusion: Musculoskeletal disorders are probably related with some fields of fatigue and burnout. Further studies should be done. Keywords: Musculoskeletal Disorders, Fatigue, Occupational Burnout, Petrochemical

Development of ListeriaBase and comparative analysis of Listeria monocytogenes

Background: Listeria consists of both pathogenic and non-pathogenic species. Reports of similarities between the genomic content between some pathogenic and non-pathogenic species necessitates the investigation of these species at the genomic level to understand the evolution of virulence-associated genes. With Listeria genome data growing exponentially, comparative genomic analysis may give better insights into evolution, genetics and phylogeny of Listeria spp., leading to better management of the diseases caused by them. Description: With this motivation, we have developed ListeriaBase, a web Listeria genomic resource and analysis platform to facilitate comparative analysis of Listeria spp. ListeriaBase currently houses 850,402 protein-coding genes, 18,113 RNAs and 15,576 tRNAs from 285 genome sequences of different Listeria strains. An AJAX-based real time search system implemented in ListeriaBase facilitates searching of this huge genomic data. Our in-house designed comparative analysis tools such as Pairwise Genome Comparison (PGC) tool allowing comparison between two genomes, Pathogenomics Profiling Tool (PathoProT) for comparing the virulence genes, and ListeriaTree for phylogenic classification, were customized and incorporated in ListeriaBase facilitating comparative genomic analysis of Listeria spp. Interestingly, we identified a unique genomic feature in the L. monocytogenes genomes in our analysis. The Auto protein sequences of the serotype 4 and the non-serotype 4 strains of L. monocytogenes possessed unique sequence signatures that can differentiate the two groups. We propose that the aut gene may be a potential gene marker for differentiating the serotype 4 strains from other serotypes of L. monocytogenes. Conclusions: ListeriaBase is a useful resource and analysis platform that can facilitate comparative analysis of Listeria for the scientific communities. We have successfully demonstrated some key utilities of ListeriaBase. The knowledge that we obtained in the analyses of L. monocytogenes may be important for functional works of this human pathogen in future. ListeriaBase is currently available at http://listeria.um.edu.my

Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae

The goal of this research was to investigate the potential of newly synthesized gold complex trichloro(2,4,6-trimethylpyridine)Au(III) as an anticancer agent. The gold(III) complex was synthesized and grafted on nanoporous silica, MCM-41, to produce AuCl3@PF-MCM- 41 (AuCl3 grafted on pyridine-functionalized MCM-41). The toxicity of trichloro(2,4,6- trimethylpyridine)Au(III) and AuCl3@PF-MCM-41 in Saccharomyces cerevisiae (as a model system) was studied. The gold(III) complex showed a mid cytotoxic effect on yeast viability. Using the drug delivery system, nanoporous MCM-41, the gold(III) complex became a strong inhibitor for growth of yeast cells at a very low concentration. Furthermore, the animal tests revealed a high uptake of AuCl3@PF-MCM-41 in tumor cells. The stability of the compound was confirmed in human serum

Quantum Corrections for a Braneworld Black Hole

By using the quantum tunneling approach over semiclassical approximations, we study the quantum corrections to the Hawking temperature, entropy and Bekenstein-Hawking entropy-area relation for a black hole lying on a brane.Comment: 8 pages, accepted for publication in IJTP, references adde

Brane-world black hole entropy from modified dispersion relations

The entropy of the Reissner-N\"{o}rdstrom black hole is studied within the context of a brane-world scenario. Such a black hole is a solution of the Einstein field equations on the brane, possessing a tidal charge which is a reflection of the extra dimension. We use the modified dispersion relation to obtain the entropy of such brane-world black holes. The resulting entropy differs from that of the standard Bekenstein-Hawking's and contains information on the extra dimension.Comment: 9 pages, 4 figures, to appear in PL

Development of ListeriaBase and comparative analysis of \u3ci\u3eListeria monocytogenes\u3c/i\u3e

Background: Listeria consists of both pathogenic and non-pathogenic species. Reports of similarities between the genomic content between some pathogenic and non-pathogenic species necessitates the investigation of these species at the genomic level to understand the evolution of virulence-associated genes. With Listeria genome data growing exponentially, comparative genomic analysis may give better insights into evolution, genetics and phylogeny of Listeria spp., leading to better management of the diseases caused by them. Description: With this motivation, we have developed ListeriaBase, a web Listeria genomic resource and analysis platform to facilitate comparative analysis of Listeria spp. ListeriaBase currently houses 850,402 protein-coding genes, 18,113 RNAs and 15,576 tRNAs from 285 genome sequences of different Listeria strains. An AJAX-based real time search system implemented in ListeriaBase facilitates searching of this huge genomic data. Our in-house designed comparative analysis tools such as Pairwise Genome Comparison (PGC) tool allowing comparison between two genomes, Pathogenomics Profiling Tool (PathoProT) for comparing the virulence genes, and ListeriaTree for phylogenic classification, were customized and incorporated in ListeriaBase facilitating comparative genomic analysis of Listeria spp. Interestingly, we identified a unique genomic feature in the L. monocytogenes genomes in our analysis. The Auto protein sequences of the serotype 4 and the non-serotype 4 strains of L. monocytogenes possessed unique sequence signatures that can differentiate the two groups. We propose that the aut gene may be a potential gene marker for differentiating the serotype 4 strains from other serotypes of L. monocytogenes. Conclusions: ListeriaBase is a useful resource and analysis platform that can facilitate comparative analysis of Listeria for the scientific communities. We have successfully demonstrated some key utilities of ListeriaBase. The knowledge that we obtained in the analyses of L. monocytogenes may be important for functional works of this human pathogen in future. ListeriaBase is currently available at http://listeria.um.edu.my

Induced inflation from a 5D purely kinetic scalar field formalism on warped product spaces

Considering a separable and purely kinetic 5D scalar field on a warped product metric background we propose a new and more general approach for inducing 4D scalar potentials on a 4D constant foliation of the 5D space-time. We obtain an induced potential for a true 4D scalar field instead of a potential for an effective 4D scalar field. In this formalism we can recover the usual 4D inflationary formalism with a geometrically induced inflationary potential. In addition the quantum confinement of the inflaton modes is obtained naturally from the model for at least a class of warping factors. Besides the 4D inflationary physics that results of this formalism is independent of the 4D-hypersurface chosen.Comment: 8 pages Accepted for publication in European Physical Journal

The Deformable Universe

The concept of smooth deformations of a Riemannian manifolds, recently evidenced by the solution of the Poincar\'e conjecture, is applied to Einstein's gravitational theory and in particular to the standard FLRW cosmology. We present a brief review of the deformation of Riemannian geometry, showing how such deformations can be derived from the Einstein-Hilbert dynamical principle. We show that such deformations of space-times of general relativity produce observable effects that can be measured by four-dimensional observers. In the case of the FLRW cosmology, one such observable effect is shown to be consistent with the accelerated expansion of the universe.Comment: 20 pages, LaTeX, 3 figure

Levels of Blood Biomarkers among Patients with Myocardial Infarction in Comparison to Control Group

BACKGROUND: Myocardial infarction (MI) as a term for a heart attack happens due to reduced blood flow to heart myocardium and lack of oxygen supply caused by plaques inthe interior walls of coronary arteries. With respect to the importance of MI etiology, we aimed to study the relationship of MI and blood examination variables.METHODS: This study was conducted in Mazandaran Heart Center as a hospital-based case-control Comprising 894 participants including 465 cases and 429 controls, individually matched by sex and age. Considered blood markers were analyzed using routine laboratory methods and equipment.RESULTS: Of all participants, 64.3% of the cases and 51.0% of the controls were males with a mean age of 61.2 (±13.8) in cases and 62.4 (±14.) in controls. We could not find any differences between cases and controls for total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and alkaline-phosphatase (ALP) (P>0.05). However, levels of creatine-kinase-muscle/brain (CK-MB) (P<0.0001), fasting-blood-sugar (FBS) (P<0.0001), aspartateaminotransferase (AST) (P<0.0001), alanine-transferase (ALT) (P<0.0001) and erythrocyte sedimentation rate (ESR) (P=0.001) were significantly higher in cases compared to the controls (P<0.05). Multivariable analyses revealed that the risk of MI was associated with high levels of AST (adjusted OR=24.3, 95%CI=3.5±165.6, P=0.001) and LDL (adjusted OR=7.4, 95%CI=1.0±51.8, P=0.001).CONCLUSION: Our investigation indicated that the levels of CK-MB, FBS, AST, ALT and ESR were significantly higher in patients with MI. Besides, our findings showed that the risk of MI in cases with high levels of AST and LDL was about 24 and 7 times more than the control group respectively